Iron-Catalyzed Highly Enantioselective Hydrosilylation of Unactivated Terminal Alkenes

The iron-catalyzed highly Markovnikov-type
selective and enantioselective
hydrosilylation of terminal aliphatic alkenes with good functional
group tolerance is developed. This operationally simple protocol uses
earth-abundant transition metal catalyst, readily available aliphatic
alkenes and hydrosilanes to construct valuable chiral organosilanes
with better than 99% ee in most cases. The chiral aliphatic alkan-2-ol
and chiral dihydroxysilane as an analogue of ketone could be efficiently
synthesized via further derivatization of chiral organosilanes without
any racemization.