Worldwide incidence and prevalence of NMO: A systematic review

Objective: Since the last epidemiologic review of neuromyelitis optica/neuromyelitis optica spectrum disorder (NMO/NMOSD), 22 additional studies have been conducted. We systematically review the worldwide prevalence, incidence, and basic demographic characteristics of NMOSD and provide a critical overview of studies. Methods: PubMed, Ovid MEDLINE, and Embase using Medical Subject Headings and keyword search terms and reference lists of retrieved articles were searched from 1999 until August 2019. We collected data on the country; region; methods of case assessment and aquaporin-4 antibody (AQP4-Ab) test; study period; limitations; incidence (per 100,000 person-years); prevalence (per 100,000 persons); and age-, sex-, and ethnic group–specific incidence or prevalence. Results: We identified 33 relevant articles. The results indicated the highest estimates of incidence and prevalence of NMOSD in Afro-Caribbean region (0.73/100 000 person-years [95% CI: 0.45–1.01] and 10/100 000 pers...研究目标：自上一次视神经脊髓炎/视神经脊髓炎谱系疾病（neuromyelitis optica/neuromyelitis optica spectrum disorder, NMO/NMOSD）流行病学综述发表以来，已有22项新增研究问世。本研究旨在系统综述全球范围内NMOSD的患病率、发病率及基本人口学特征，并对现有研究开展批判性综述。 研究方法：本研究于1999年至2019年8月期间，检索PubMed、Ovid MEDLINE及Embase数据库，采用医学主题词与关键词组合进行检索，并回溯纳入文献的参考文献列表。本研究收集的资料包括：研究涉及的国家与地区、病例评估及水通道蛋白4抗体（aquaporin-4 antibody, AQP4-Ab）检测方法、研究周期、研究局限性、发病率（以每10万人年为单位）、患病率（以每10万人为单位），以及按年龄、性别、种族分组的发病率或患病率数据。 研究结果：本研究共纳入33篇相关文献。结果显示，非裔加勒比地区的NMOSD发病率与患病率估算值最高：发病率为0.73/10万人年（95%置信区间：0.45~1.01），患病率为10/100 000人……