Transcriptome profiling of muscle from control, mdx and Sirt6 knockout on mdx background mice

In this study, Pax7-Cre mediated inactivation of Sirt6 in mdx mice resulted in profound improvement of the mdx phenotype at the functional level. To study the underlying molecular mechanisms we performed RNA-seq of muscles from control, mdx and Sirt6mKO/mdx mice. RNA-seq analysis of muscle from control (wild type), mdx and Sirt6mKO/mdx mice本研究中，Pax7-Cre介导的mdx小鼠体内沉默信息调节因子6（Sirt6）的失活，可使mdx小鼠的表型在功能层面得到显著改善。为探究其潜在的分子机制，我们对对照组、mdx小鼠及Sirt6mKO/mdx小鼠的肌肉组织进行了RNA测序（RNA-seq），并针对对照组（野生型）、mdx小鼠及Sirt6mKO/mdx小鼠的肌肉组织开展了RNA-seq分析。