The plasma metabolome from the control and CSF mice was quantified with a high throughput targeted metabolite (HM350 Metabolome). 20 μL of plasma samples and standards were added to Eppendorf vials co
C7–10 and BSC40 cells were grown for 16 hr in 6-well plates in media with different concentrations of methionine. AdoMet was extracted and measured as described under Materials and Methods. Total cell