Differential gene expression during embryoid body (EB) formation of mouse embryonic stem cells when Hnrnpll was depleted

This work indicates Hnrnpll depletion mES cells cannot exit from pluripotency programme, showing embryoid body formation deficiency and no spontaneous differentiation withdraw LIF. Hnrnpll promotes multiple ES cell preferred-exon skipping during ES cells differentiation, to reduce the ES cells specific isoform and facilitate ES cells exit from pluripotency towards differentiation. Overall design: polyA+ RNA profiles of wildtype or Hnrnpll-/- mESC EB differentiation at day 0, 4, 8.