hALK in complex with 1-[(1R,2R)-1-(2,4-difluorophenyl)-2-[2-(5-methyl-1H-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine
收藏Protein Data Bank Japan2023-10-18 更新2026-03-21 收录
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hALK in complex with 1-[(1R,2R)-1-(2,4-difluorophenyl)-2-[2-(5-methyl-1H-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine Descriptor: 1,2-ETHANEDIOL, 4-{[(1R,2R)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1H-pyrazol-3-yl)benzonitrile, ALK tyrosine kinase receptor Authors: McGrath, A.P, Zou, H, Lane, W, Saikatendu, K. Deposit date: 2020-08-31 Release date: 2021-01-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design. Acs Omega, 5, 2020
人类间变性淋巴瘤激酶（human Anaplastic Lymphoma Kinase, hALK）与1-[(1R,2R)-1-(2,4-二氟苯基)-2-[2-(5-甲基-1H-吡唑-3-基)-4-(三氟甲基)苯氧基]环丙基]甲胺的复合物
描述项：1,2-乙二醇，4-{[(1R,2R)-2-(2,4-二氟苯基)环丙基]氧基}-3-(5-甲基-1H-吡唑-3-基)苄腈
作者：McGrath, A.P、Zou, H、Lane, W、Saikatendu, K.
入库日期：2020-08-31
发布日期：2021-01-20
最后修改日期：2023-10-18
检测方法：X射线衍射（2.32 Å）
引用文献：Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design，发表于《ACS Omega》2020年第5卷
创建时间：
2020-08-31
