Replication in the AJCS subject set.

List of the SNPs in ADARB2 and ADARB1 that reach statistical significance in the NECS and SICS and were attempted to be replicated in the AJCS set. The first 7 columns report the details of the SNPs as described in the legend of Table 3. Columns 8–11 report the results for 14 of the 18 SNPs in Table 3 that were genotyped in 255 oldest old and 227 younger controls of the AJCS. Only 3 SNPs reach statistical significance in this set (rows 3, 13 and 14) but two of them have opposite effects compared to the NECS and SICS (rows 13 and 14). However, SNPs in rows 1, 5–9, 11 and 12 have effects that are consistent with the NECS and SICS and, when the data of the 3 studies are aggregated, they become significant (columns 12–14). The SNPs in rows 2, 4, 10 and 11 were not typed because proxy SNPs from an ongoing genome wide association study conducted with the Affymetrix 6.0 array suggest strong associations in the same region.