PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with starting material
收藏Protein Data Bank Japan2026-02-18 更新2026-03-21 收录
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PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with starting material Descriptor: 2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxylic acid, PH-interacting protein Authors: Grosjean, H, Aimon, A, Hassel-Hart , S, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Biggin, P.C, Spencer, J, von Delft, F. Deposit date: 2021-01-22 Release date: 2021-02-17 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography. Angew.Chem.Int.Ed.Engl., 64, 2025
PanDDA分析组提交数据集——与起始原料结合的PHIP晶体结构：起始原料的描述符为2,3-二氢噻吩并[3,4-b][1,4]二恶英-5-羧酸，PHIP即为PH相互作用蛋白（PH-interacting protein）。作者：Grosjean, H、Aimon, A、Hassel-Hart, S、Krojer, T、Talon, R、Douangamath, A、Koekemoer, L、Biggin, P.C、Spencer, J、von Delft, F。提交日期：2021-01-22，发布日期：2021-02-17，最后修改日期：2026-02-18。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.18埃）。引用文献：《活性物质结合位点纯化法（Binding-Site Purification of Actives，缩写B-SPA）可通过结合多步阵列合成与高通量晶体学（HT Crystallography）实现片段命中化合物（Fragment Hits）的高效规模化推进》，Angew.Chem.Int.Ed.Engl., 64, 2025
创建时间：
2021-01-22
