Genome-wide maps of LADs distribution in control and Dam-WT/Dam-R527C LMNA stabilized Hela cells

To determine if LMNA R527C mutation affect the arrangement and function of LADs, we performed Lamin A DamID-seq in wild type and mutant LMNA-stablized Hela cells. Reads of Lamin A ChIP-seq in LADs were decreased in mutant cells compared with wild type. These data suggested that the binding affinity of Lamin A to LADs was reduced after R527C mutation Overall design: To determine if R527C mutation affects the arrangement and function of LADs, we performed Lamin A DamID-seq in control and Dam-WT/Dam-R527C LMNA stabilized Hela cells. Examination of LADs distribution in control and Dam-WT/Dam-R527C LMNA stabilized Hela cells.