Proposed sequence of events for GroEL encapsulation, based upon results from the present study.

In this figure, ideas derived from the present study are illustrated in yellow text bubbles, ideas based upon prior studies [20]–[22] are illustrated in the blue text bubble. The scheme is based on the characteristics displayed by numerous mutant forms of GroEL that highlight certain dependencies between individual molecular events. Kinetic phases detected in our stopped-flow experiments are indicated in blue text, names of individual mutants are denoted in red text, and green text indicates proposed correlations and conclusions derived from comparisons of our results with various previous studies. Details are given in the main text.

本图绘制的黄色文字气泡展示了本研究中提炼的见解，而基于先前研究[20]–[22]的见解则体现在蓝色文字气泡中。该方案建立在多种GroEL突变体所展现的特性之上，突显了个体分子事件之间的某些依赖关系。在停止流动实验中检测到的动力学阶段以蓝色文字标注，个体突变体的名称以红色文字标示，绿色文字则表明了通过将我们的研究结果与各种先前研究进行比较而提出的关联和结论。具体细节将在正文部分阐述。