Isatin Derived Spirocyclic Analogues with α‑Methylene-γ-butyrolactone as Anticancer Agents: A Structure–Activity Relationship Study
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https://figshare.com/articles/dataset/Isatin_Derived_Spirocyclic_Analogues_with_Methylene_butyrolactone_as_Anticancer_Agents_A_Structure_Activity_Relationship_Study/3201964
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资源简介：
Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogues and their evaluation as anticancer agents is described. SAR identified a spirocyclic analogue 19 that inhibited TNFα-induced NF-κB activity, cancer cell growth and tumor growth in an ovarian cancer model. A second iteration of synthesis and screening identified 29 which inhibited cancer cell growth with low-μM potency. Our data suggest that an isatin-derived spirocyclic α-methylene-γ-butyrolactone is a suitable core for optimization to identify novel anticancer agents.
创建时间：
2016-05-20
