The inflammasome is a central player in the induction of obesity and insulin resistance

ChEBI2011-08-20 更新2026-07-21 收录

代谢免疫学

肥胖机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-25205 数据链接链接失效反馈

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The inflammasome is a central player in the induction of obesity and insulin resistance

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2011-08-20

High diet treatment on cohoused and single housed WT and Nlrp12 ko mice. High diet treatment on cohoused and single housed WT and Nlrp12 ko mice

肥胖机制

肠道菌群互作

We found Nlrp12 ko mice are more prone to high fat diet (HFD) induced obesity process. And this expedited obesity is affected by commensal bacterial composition. When cohoused WT and Nlrp12 ko mice du

NIAID Data Ecosystem130

Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice

代谢物生物标志物

肥胖机制

Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome. Development of obesity is also linked to changes in fat

Figshare2016-05-20 更新50

An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice

基因功能验证

肥胖机制

Chronic antagonism of melanocortin receptors by the paracrine-acting agouti gene product induces both yellow fur and a maturity-onset obesity syndrome in mice that ubiquitously express wild-type agout

PubMed Central1999-07-20 更新30

Bvul restores Am-depleted dysbiosis: mouse shotgun

消化道微生物组

肥胖机制

Weight loss and exercise intervention studies report an interaction between Bacteroides (Bvul) and Akkermansia (Am), although the underlying mechanism(s) and consequences of the interaction remain unk

NIAID Data Ecosystem70

Cytokine Signaling Co-opts the CREB/CRTC Pathway in Obesity

肥胖机制

代谢信号通路

Obesity stimulates the infiltration of adipose tissue by innate immune cells, which in turn promote insulin resistance via the NFkB mediated induction of pro-inflammatory cytokines, which interfere wi

NIAID Data Ecosystem40

The inflammasome is a central player in the induction of obesity and insulin resistance

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