Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
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Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X. Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ... Authors: Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K. Deposit date: 2007-01-30 Release date: 2007-05-22 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50, 2007
L100I突变型HIV-1逆转录酶与GW420867X复合物的晶体结构。配体描述：(2S)-2-乙基-7-氟-3-氧代-3,4-二氢喹喔啉-1(2H)-羧酸异丙酯、磷酸根离子、逆转录酶/核糖核酸酶H（Reverse transcriptase/ribonuclease H）等。作者：Ren, J、Nichols, C.E、Chamberlain, P.P、Weaver, K.L、Short, S.A、Chan, J.H、Kleim, J、Stammers, D.K。沉积日期：2007-01-30；发布日期：2007-05-22；末次修改日期：2024-10-30。实验方法：X射线衍射（2.8 Å）。引用文献：《GW420867X的效力与抗药性突变适应性的关系——基于野生型、Leu100Ile、Lys101Glu及Tyr188Cys突变型HIV-1逆转录酶抑制剂复合物晶体结构》，J.Med.Chem., 50, 2007
创建时间：
2007-01-30
