Exploring lipid dynamics in animal organs affected by inhaled particulate matter through quasi-elastic neutron scattering (QENS)

The experiments proposed involve utilizing the OSIRIS instrument at ISIS to conduct Quasi-elastic neutron scattering (QENS) experiments. These experiments aim to investigate the dynamics of lipids affected by particles within a complex and advanced biological system. To move beyond cellular models, the proposed experiment will assess lipid dynamics in key organs (e.g., lung and brain) derived from animal experiments. This will involve comparing conditions with and without inhaled particles, as well as comparing between healthy and compromised conditions under inflammatory status.