Expression data from SH-SY5Y neuroblastoma cells treated with the protein disulfide isomerase inhibitor origamicin
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129171
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Protein disulfide isomerase (PDI) is associated with many diseases including neurodegenerative disorders like Alzheimer’s disease and, hence, is considered a promising drug target. In this study, we investigate the abscisic acid (ABA)-derived PDI inhibitor origamicin for its neuropharmacological potential. We used microarrays to analyze the global change in gene expression as a result of PDI inhibition in the human neuroblastoma cell line SH-SY5Y We treated SH-SY5Y cells with the PDI inhibitor Origamicin (30 uM) for 24 h and then extracted the global RNA. We subjected the RNA to an Affymetrix® Human Gene 2.0 ST Array
创建时间:
2021-01-02



