Fluorescence micrographs demonstrating the distribution of inherently fluorescent Janus kinase 3 inhibitors

The dataset contains supplementary images for the publication "Inherent fluorescence demonstrates immunotropic properties for novel Janus kinase 3 inhibitors". In short, cells were incubated with fluorescent JAK3 inhibitors or control fluorophore 13 (appearing in green) as well as stains for lysosomes (appearing in red) or nuclei (appearing in blue). For in vivo samples (tail blood and organs), C57/BL6 mice were treated p.o. with the aforementioned JAK3 inhibitors or the control. Again, nuclei were stained blue and compounds appear in green. File names indicate the test compound used (1-13), the sample type (cell type or organ), incubation time (for in vitro samples), sampling time post treatment (for in vivo tail blood samples) and the level of magnification. "Overlay" indicates a merge of channels for compound fluorescence, lysosome and nucleus stains. "Overview" indicates a merge of singular captures to give an overview of the entire organ sample. HBC = human buffy coat HMC3 = human microglia cells PBMCs = peripheral blood mononucleated cells