RNA-seq of wildtype and JADE1/2/3 knockout mIMCD3 kidney cells. RNA-seq of wildtype and JADE1/2/3 knockout mIMCD3 kidney cells

JADE family proteins (JADE1/2/3) have been implicated in diverse cellular functions and signaling pathways ranging from WNT signaling and cell cycle control to cell death and complex transcriptional regulation through histone acetyl-transferase complexes. However, the function of the widely expressed JADE proteins at the molecular level is still elusive. Using kidney cells (mIMCD3) as a model, we demonstrate that loss of either JADE protein resulted in increased expression of almost all components of the 26S proteasome. These data may now help to explain the plethora of cellular roles that have been attributed to JADE proteins.