Crystal Structure of the metallo-beta-lactamase L1 from Stenotrophomonas maltophilia in the complex with the hydrolyzed penicillin G

Crystal Structure of the metallo-beta-lactamase L1 from Stenotrophomonas maltophilia in the complex with the hydrolyzed penicillin G Descriptor: (2R,4S)-2-{(R)-carboxy[(phenylacetyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, DI(HYDROXYETHYL)ETHER, Putative metallo-beta-lactamase l1 (Beta-lactamase type ii) (Ec 3.5.2.6) (Penicillinase), ... Authors: Kim, Y, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2019-08-15 Release date: 2019-09-11 Last modified: 2026-03-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural and biochemical analysis of the metallo-beta-lactamase L1 from emerging pathogen Stenotrophomonas maltophilia revealed the subtle but distinct di-metal scaffold for catalytic activity. Protein Sci., 29, 2020

嗜麦芽窄食单胞菌（Stenotrophomonas maltophilia）来源的金属β-内酰胺酶（metallo-beta-lactamase）L1与水解青霉素G复合物的晶体结构。描述项：(2R,4S)-2-{(R)-羧基[(苯乙酰基)氨基]甲基}-5,5-二甲基-1,3-噻唑烷-4-羧酸、二(羟乙基)醚（DI(HYDROXYETHYL)ETHER）、推定金属β-内酰胺酶L1（β-内酰胺酶II型，EC 3.5.2.6，青霉素酶）……作者：Kim Y、Maltseva N、Endres M、Joachimiak A，传染病结构基因组学中心（CSGID）；提交日期：2019-08-15；发布日期：2019-09-11；最后修改日期：2026-03-25；实验方法：X射线衍射（分辨率1.65埃）；引用文献：对新兴病原体嗜麦芽窄食单胞菌来源的金属β-内酰胺酶L1的结构与生化分析，揭示了其催化活性所依赖的微妙且独特的双金属支架结构。《Protein Science》，29卷，2020年。