Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP

Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with compound 382 and UDP Descriptor: 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, GLYCEROL, Histo-blood group ABO system transferase, ... Authors: Palcic, M.M, Jorgensen, R. Deposit date: 2011-09-29 Release date: 2012-10-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding To be Published

岩藻糖基半乳糖苷α-N-乙酰半乳糖胺基转移酶 (Fucosylgalactoside alpha N-acetylgalactosaminyltransferase，简称GTA，cisAB突变体L266G、G268A) 与化合物382及尿苷二磷酸 (UDP) 结合形成复合物的晶体结构。描述项：1-(3-苯基-1,2,4-噻二唑-5-基)哌嗪、甘油 (GLYCEROL)、组织血型ABO系统转移酶 (Histo-blood group ABO system transferase) 等；作者：Palcic M.M.、Jorgensen R.；入库日期：2011年9月29日；发布日期：2012年10月24日；最后修改日期：2023年9月13日；实验方法：X射线衍射 (X-RAY DIFFRACTION，分辨率1.6埃)；引用文献：通过分子片段库筛选获得的新型化合物可通过置换金属离子并干扰底物结合的方式抑制糖基转移酶，待发表。