Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures

We describe the global cell fate roadmap during primed-to-naive transition process by bulk mRNA-seq and ATAC-seq analysis among transition intermediates across different time points. We report that activation of ALPG is a landmark event for naive state establishment. Further investigation into transitioning cells with dynamic fluorescence presents intermediates branching into TE-like subpopulations with capacities of TSC derivation. Overall design: Analyzing mRNA-seq and ATAC-seq profiles of transitioning intermediates during primed-to-naive transition process.