08.06.2022_SourceFile_RNA-seq.xlsx

In heterogeneous head and neck cancer (HNC), subtype-specific treatment regimens are currently missing. An integrated analysis of patient HNC subtypes using single-cell sequencing and proteome profiles revealed a hallmark epithelial-mesenchymal transition (EMT) signature within the epithelial cancer-cell population. The EMT signature was evident in the invasive mesenchymal subtype and importantly, coincided with PI3K/mTOR pathway inactivation. Conversely, the signature was suppressed in epithelial cancer cells of the basal subtype which exhibits hyperactive PI3K/mTOR oncogenic signalling.