Regulation of lung EC transcriptome by leene in mouse

Vascular endothelial cells play a pivotal role in whole-body homeostasis. To test the function of LEENE in vivo, particularly in the context of hypertension, we subjected WT and leene-KO mice to an Angiotensin II-induced hypertension model. We then profiled the transcriptomic changes in the EC-enriched fractions of the lung. PolyA-enriched RNA-seq in lung endothelial cells of leene WT and KO mice supplemented with AngII implantation