Physical and functional interaction between Irf8 enhancers during dendritic cell differentiation
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https://www.ncbi.nlm.nih.gov/sra/DRP011504
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资源简介：
To understand the roles of Irf8 3' enhancers on Irf8 expression during cDC1 differentiation, we performed Tiled-C analysis of bone marrow cells and splenocytes from wild-type mice. The integrated analysis of transcriptome, histone modification, and higher-order chromatin structures in these mouse mononuclear phagocytic lineage cells revealed that the +56 kb enhancer acts on other 3' enhancers via an IRF8-dependent TF program and the +32 kb enhancer acts in cis to activate other 3' enhancers.
创建时间：
2024-04-26
