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Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

ChEBI2014-12-04 更新2026-07-21 收录

组织特异性免疫

表观遗传增强子

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-62826 数据链接链接失效反馈

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Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

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创建时间：

2014-12-04

树突状细胞分化

组织特异性免疫

Committed precursors of conventional dendritic cells (pre-cDCs) derived from the common DC progenitor which differentiate into cDC subpopulations in peripheral tissues have been identified, but commit

NIAID Data Ecosystem120

BET bromodomain proteins regulate enhancer function during adipogenesis. BET bromodomain proteins regulate enhancer function during adipogenesis

脂肪细胞分化

表观遗传增强子

Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in expression of PPARg and C/EBPa, which orchestrate activati

NIAID Data Ecosystem50

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity

ILC组织分布与异质性

组织特异性免疫

We provide a map of human ILC heterogeneity across multiple anatomical sites. Tissue-specific distinctions are particularly apparent for ILC1 populations, whose distribution was markedly altered

NIAID Data Ecosystem40

Genome wide mapping of NR4A binding reveals cooperativity with ETS factors to promote epigenetic activation of distal enhancers in acute myeloid leukemia cells [array]. Homo sapiens

白血病转录调控

表观遗传增强子

NR4As are critical tumor suppressors of acute myeloid leukemia (AML) whose expression is broadly silenced in leukemia initiating cell enriched populations from human patients relative to normal hemato

NIAID Data Ecosystem50

Expression data from invariant natural killer T (iNKT) cells in spleen and adipose tissue

组织特异性免疫

基因表达谱分析

Adipose tissue iNKT cells have different functions than iNKT cells in the blood and other organs. We used microarrays to detail the global gene expression profiles that might underlie these phenotypic

NIAID Data Ecosystem40

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

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