Mettl3 regulates late retinogenesis. Mettl3 regulates late retinogenesis

Mettl3 was conditionally knocked out from retinal progenitor cells. Metll3 deficient retinas exhibited disrupted cell cycle during late retinogenesis and abnormality in retinal architecture and physiology. Overall design: 2 control and 2 Mettl3-conditional knockout retinas (from the same litter at postnatal day 7) were dissociated into single cells, and processed using 10X Genomics Chrominum to prepare scRNAseq libraries. 2 control retinas were mixed together as one control sample, and 2 mutant retinas were processed together as one mutant sample.