A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease

The interplay between the gut microbiota, bile acids and the immune is a critical determinant in development of inflammatory bowel disease (IBD). Here investigated the fecal bile acid profiles, gut microbiota composition, and immune responses in IBD patients and murine models of colitis.肠道菌群（gut microbiota）、胆汁酸与免疫系统之间的相互作用，是炎症性肠病（inflammatory bowel disease, IBD）发生发展的关键决定因素。本研究针对炎症性肠病患者及结肠炎小鼠模型，对其粪便胆汁酸谱、肠道菌群组成与免疫应答展开了探究。