NRBF2 coiled coil domain promotes autophagy by strengthening association with Vps15 in the PI3KC3 complex
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NRBF2 coiled coil domain promotes autophagy by strengthening association with Vps15 in the PI3KC3 complex Descriptor: Nuclear receptor-binding factor 2 Authors: Li, N, Zhao, Y. Deposit date: 2025-09-15 Release date: 2025-11-12 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (2.25 Å) Cite: NRBF2 homodimerization by its coiled-coil domain strengthens association with the PtdIns3K complex mediated by the MIT domain to promote autophagy. Autophagy, 22, 2026
NRBF2卷曲螺旋结构域通过增强与PI3KC3复合物中Vps15的结合促进自噬 描述(Descriptor):核受体结合因子2(Nuclear receptor-binding factor 2, NRBF2) 作者(Authors):Li, N.、Zhao, Y. 提交日期(Deposit date):2025-09-15 发布日期(Release date):2025-11-12 最后修改日期(Last modified):2026-01-07 实验方法(Method):X射线衍射(分辨率2.25埃) 引用(Cite):NRBF2通过其卷曲螺旋结构域发生同源二聚化,增强其与MIT结构域介导的磷脂酰肌醇3-激酶(PtdIns3K)复合物的结合,进而促进自噬。《自噬》,22卷,2026年



