Proteinuria in G1/G1 mice (raw data) treated with lisinopril and untreated

Here I studied the effect of lisinopril in the G1/G1 mouse model. Most G1/G1 mice survived the four-week experimental period with ongoing proteinuria and moderate to severe (morphologically defined) FSGS, but a few mice with more severe disease died between weeks two and four. This table represents pooled data from two separate experiments; one terminated at day 38, and another continued to day 60 to assess survival. 24 G1/G1 mice were injected with the pCpG free interferon ɤ plasmid. To exclude any injected mice that did not develop kidney disease, we confirmed the presence of proteinuria by SDS PAGE chromatography of urine at day seven post-injection and only proteinuric mice were randomized to either treatment or control groups (12 mice each). Lisinopril was administered in the drinking water at 75 mg/L, and the control group received water without drug. Urine was collected twice a week. The first group of mice was sacrificed for analysis on day 38 post-injection. Proteinuria (raw data) is expressed as ugAlbumin/mg Creatinine.