Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one Descriptor: (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one, ALK TYROSINE KINASE RECEPTOR Authors: McTigue, M.A, Deng, Y.L, Liu, W, Brooun, A, Stewart, A.E. Deposit date: 2014-01-17 Release date: 2014-05-28 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of (10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo[4,3-H][2,5,11]Benzoxadiazacyclotetradecine-3-Carbonitrile (Pf-06463922), a Macrocyclic Inhibitor of Alk/Ros1 with Pre-Clinical Brain Exposure and Broad Spectrum Potency Against Alk-Resistant Mutations. J.Med.Chem., 57, 2014

人类间变性淋巴瘤激酶（Anaplastic Lymphoma Kinase, ALK）与抑制剂(10R)-7-氨基-12-氟-1,3,10,16-四甲基-16,17-二氢-1H-8,4-(亚甲基)吡唑并[4,3-h][2,5,11]苯并氧二氮杂环十四烷-15(10H)-酮的复合物结构。
描述符：(10R)-7-氨基-12-氟-1,3,10,16-四甲基-16,17-二氢-1H-8,4-(亚甲基)吡唑并[4,3-h][2,5,11]苯并氧二氮杂环十四烷-15(10H)-酮、ALK酪氨酸激酶受体
作者：McTigue, M.A.、Deng, Y.L.、Liu, W.、Brooun, A.、Stewart, A.E.
提交日期：2014-01-17
发布日期：2014-05-28
最后修改日期：2023-12-20
解析方法：X射线衍射（分辨率1.8埃）
引用文献：《(10R)-7-氨基-12-氟-2,10,16-三甲基-15-氧代-10,15,16,17-四氢-2H-8,4-(亚甲基)吡唑并[4,3-h][2,5,11]苯并氧二氮杂环十四烷-3-甲腈(PF-06463922)：一种兼具临床前脑暴露活性与ALK耐药突变广谱抑制活性的大环ALK/ROS1抑制剂的发现》，《药物化学杂志》(J. Med. Chem.)，57卷，2014年