<b>Raw data in metabolomic profiling and analysis</b>

In this study, we identify a significant induction of a CD81+ erythroblast subpopulation in the spleens of an AML mouse model, which can promote AML cell proliferation and reduce mice survival. To investigate the metabolic alterations induced by CD81+ Erys co-culture, AML cells (NT or Egln3_KO) were cultured under three different conditions: co-cultured with CD81+ Erys, co-cultured with CD81− Erys, or cultured alone. AML cells were lysed to extract intracellular metabolites for liquid chromatography-mass spectrometry (LC-MS) analysis after co-cultured.