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Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

ChEBI2014-08-18 更新2026-07-21 收录

发育表观遗传调控

突触可塑性

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-57758 数据链接链接失效反馈

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Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

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创建时间：

2014-08-18

神经科学

突触可塑性

Neurological diseases can lead to the denervation of brain regions caused by demyelination, traumatic injury or cell death. The molecular and structural mechanisms underlying lesion-induced reorganiza

DataONE2024-01-12 更新180

ATAC-seq of progenitors and neurons from human brain organoids. ATAC-seq of progenitors and neurons from human brain organoids

发育表观遗传调控

类器官模型

During development of the human cerebral cortex, multipotent neural progenitors generate excitatory neurons and glial cells. This process is faithfully recapitulated in brain organoids. By using telen

NIAID Data Ecosystem30

m6A/YTHDF1 modulates CAP1-mediated actin turnover and synaptic function to regulate anxiodepressive-like behaviors [RIP-Seq]

抑郁神经机制

突触可塑性

Neuroplasticity and synaptic dysfunction are central to depression, yet the underlying mechanisms remain poorly understood. While m6A and its reader YTHDF1 regulate mRNA translation, neuroplasticity a

NIAID Data Ecosystem10

DNA Methyaltion of Human Cortical Organoids

发育表观遗传调控

器官DNA甲基化

Assesing DNA methylation patterns of human cortical organoids during long term (>600 days) maturation. 52 samples collected during long term maturation of human cortical spheroids

NIAID Data Ecosystem90

Catalytic activity of nuclear METTL3 promotes functional m6A modifications that drive retinal development [mRNA-seq]

发育表观遗传调控

m6A修饰分析

METTL3 catalyzes N6-methyladenosine (m6A) on mRNA, regulating RNA metabolism, but its role in early retinal development remains virtually unstudied. Using stem cell-derived 3D retinal organoids to mod

NIAID Data Ecosystem10

Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

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