Predictive factors at 4-year follow-up of very low adherent (n = 2,178) compared to high adherent (n = 1,501) to the statin treatment.

*Adherence level was categorized according to the MPR: very low (MPR≤25%); high (MPR≥80%).&Odds Ratio as measure of probability of being very low adherent to the statin treatment compared the users being high adherent. All the covariates significantly associated with the non-adherence in the first model have been included in the full adjusted model.#Other cardiovascular risk factors include cardiomyopathies, valve disorders, arrhythmias, or atrial flutter/fibrillation, heart failure, or congenital heart disease.$Absence of comorbidity as reference.▾Users of atorvastatin have been defined as reference group because atorvastatin resulted the most prescribed statins in this specific subcohort of analysis and, overall, in Italy, as reported in OSMED; in addition, the choice is consistent with a previous published study on predictors of adherence [3], [28], [36], [37]Abbreviations: MPR: Medication Possession Ratio; OR = Odds Ratio; CI = confidence interval.