Assesment of Peripheral Blood Mononuclear Cells Responce Exposed to Staphylococcus aureus Biofilms and Planktonic Bacteria

Staphylococcus aureus is one of the most successful human pathogens. It is the leading cause of a multitude of healthcare-associated, community-acquired, and acute-to-chronic infectious diseases. Bacteria can benefit from host signals during infection. Immune cells such as monocytes are able to secrete chemokine upon facing planktonic bacteria or their products. Host immune regulatory chemokine is capable to trigger planktonic S. aureus to releases its virulence factor to evade the immune response. Chemokine binding may facilitate immune evasion by S. aureus, however, the biofilm ability to induce chemokine secretion remains unknown. Also, Understanding the immune response to biofilms is critical for developing effective diagnostics and treatments for biofilm associated infections, as bacteria in biofilms differ in their resistance to antibiotics and host immune response.