Expression profiling and pathway analyses of prostate cancer cell lines

This dataset is for an MSc study titled 'Molecular profiling of long non-coding RNAs in prostate cancer cell lines' illustrating each of the main components of the project. In this study, RNA from two prostate cancer cell lines (LNCaP and PC-3 cells) was subjected to microarray profiling. The expression of long noncoding RNAs (lncRNAs) of the two cell lines were compared. The differentially expressed lncRNAs were further analyzed to establish which cancer hallmarks and molecular pathways they are involved in. Their miRNA interactions were further elucidated and a competing endogenous RNA (ceRNA) network was constructed. The data revealed that the differentially expressed lncRNAs are involved in prostate cancer metastasis and proliferation. Their interaction with miRNAs is a mechanism by which these molecules promote cancer progression.

本数据集旨在支持一项名为《前列腺癌细胞系中长非编码RNA的分子特征分析》的硕士研究生研究，详细阐述了该项目的主要组成部分。在该研究中，对来自两种前列腺癌细胞系（LNCaP和PC-3细胞）的RNA进行了微阵列分析。比较了两种细胞系中长非编码RNA（lncRNA）的表达情况。对差异表达的lncRNA进行了进一步分析，以确定它们所涉及的癌症标志物和分子通路。进一步阐明了它们与miRNA的相互作用，并构建了一个竞争性内源RNA（ceRNA）网络。数据分析结果表明，差异表达的lncRNA参与前列腺癌的转移和增殖。它们与miRNA的相互作用是这些分子促进癌症进展的机制之一。