官方服务：
资源简介：
Homology-driven Genome Editing in human T Cells
应用场景：
创建时间：
2015-07-10
相关数据集
The spliceosome-associated protein Nrl1 promotes DNA repair and suppresses R-loop formation in fission yeast
The formation of RNA-DNA hybrids referred as to R-loops can promote genome instability and cancer development. Yet the mechanisms by which R-loops compromise genome instability are poorly understood.
NIAID Data Ecosystem50
Mechanism of homology search expansion during recombinational DNA break repair. Saccharomyces cerevisiae W303
Hi-C and ssHi-C paired-end Illumina reads generated as part of the work "Mechanism of homology search expansion during recombinational DNA break repair"
NIAID Data Ecosystem20
PRMT5 regulates the homologous recombination DNA repair pathway by controlling the alternative splicing of key epigenetic factors
We found that PRMT5 deletion or inhibition impairs homologous recombination (HR) DNA repair, leading to DNA damage accumulation, p53 activation, cell cycle arrest and cell death through missplicing of
Alliance of Genome Resources10
The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination
RAD51 recombinase polymerizes at the site of double-strand breaks (DSBs) where it performs DSB repair. The loss of RAD51 causes extensive chromosomal breaks, leading to apoptosis. The polymerization o
NIAID Data Ecosystem30
List of oligonucleotides.
Primers 1–5 were used to isolate and modify the cDNA encoding E. histolytica DMC1 and RAD51. H3, OL83-1, and OL90 were 32P-radiolabeled using [32P-γ]-ATP and T4-PNK. 32P-H3 and 32P-OL83-1 were anneale
NIAID Data Ecosystem20
