Crystal structure of human 15-PGDH in complex with small molecule compound 1

Crystal structure of human 15-PGDH in complex with small molecule compound 1 Descriptor: (4S)-7-[7-(4,4-difluoropiperidine-1-carbonyl)-2,3-dihydro-4H-1,4-benzoxazin-4-yl]-2-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, 1,2-ETHANEDIOL, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], ... Authors: Shaik, M.M, Brennan, D. Deposit date: 2025-07-05 Release date: 2025-09-10 Last modified: 2025-09-17 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors. J.Med.Chem., 68, 2025

人类15-羟基前列腺素脱氢酶（15-PGDH）与小分子化合物1结合的晶体结构。描述项：(4S)-7-[7-(4,4-二氟哌啶-1-羰基)-2,3-二氢-4H-1,4-苯并恶嗪-4-基]-2-甲基[1,2,4]三唑并[4,3-a]吡啶-3(2H)-酮、1,2-乙二醇、15-羟基前列腺素脱氢酶[NAD(+)]等。作者：Shaik, M.M、Brennan, D.。提交日期：2025-07-05；发布日期：2025-09-10；最后修改日期：2025-09-17。实验方法：X射线衍射（分辨率1.65 Å）。引用文献：《15-PGDH抑制剂的知识与基于结构的药物设计》，《药物化学杂志》（J.Med.Chem.），第68卷，2025年。