Megastructure Design and Image Dataset Accompanying the Preprint "A computational framework for designing micron-scale crisscross DNA megastructures"

This dataset contains all the designs, electron micoscopy images and analyses used for our paper entitled 'A computational framework for designing micron-scale crisscross DNA megastructures' which has been submitted for peer-review. This dataset also acts as the accompaniment for our software, #-CAD, which can be downloaded from https://github.com/mattaq31/Hash-CAD or accessed directly at https://www.hash-cad.com. Link to paper coming soon. The dataset is split according to each figure in the main paper: The figure 4 folder contains the design file and exemplary microscope images for each different megastructure shown. The figure 5 folder contains the designs, original microscopy data and particle counting results used for the figure data. The figure 6 folder contains the designs, original microscopy data and particle counting results used for the figure data. The figure 7 folder contains the zigzag design, original microscopy data and particle counting results used for the figure data. The ext fig 1 folder contains the original microscopy data and particle counting results used for the figure data. The ext fig 2/3 folder contains the results of all the runs used to test the different hyperparameters of the evolutionary algorithm. This project was supported by various funding sources: A UK Medical Research Council Precision Medicine Transition Fellowship awarded to Matthew Aquilina (grant number MR/N013166/1) The Dana-Farber Cancer Institute's Claudia Adams Barr Program for Cancer Research A Wyss Institute Northpond Alliance Director's Fund Award awarded to Matthew Aquilina The German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) through the Walter Benjamin Programme (project number 553862611, awarded to Florian Katzmeier) The U.S. Department of Energy, Office of Science, Basic Energy Sciences, Biomolecular Materials Program (Award No. DE-SC0024136) The Carlsberg Foundation (grant CF23-1125, awarded to Minke Nijenhuis) A Sloan foundation grant (grant ID G-2021-16495) The Harvard College Research Program (funding Corey Becker) The Korea-US Collaborative Research Fund (KUCRF) funded by the Ministry of Science and ICT and Ministry of Health & Welfare, Republic of Korea (grant RS-2024-00468463) The Novo Nordisk Foundation (grant NNF23OC0084494) The Wyss Institute's Molecular Robotics Initiative