androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng. Mus musculus

NIAID Data Ecosystem2026-05-02 收录

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androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng

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2024-07-27

MAT2A promotes reprogramming of the androgen response pathway in association with ERG and EZH2

前列腺癌治疗

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To date there are very few tools to reverse the induced dedifferentiation program in CRPC and to improve the response to the androgen deprivation therapy. Here we report that MAT2A is an important onc

NIAID Data Ecosystem70

Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in sertoli cells

支持细胞功能调控

精子发生

To elucidate the role(s) of WNT/CTNNB1 signaling in the testis, transgenic Ctnnb1 tm1Mmt/+;Amhr2 tm3(cre)Bhr/+ mice were generated to obtain sustained activation of the WNT/CTNNB1 pathway in Sertoli c

NIAID Data Ecosystem60

Contribution of SRF and Nkx2-5 to androgen-dependent gene expression in prostate cancer

前列腺癌转录组学

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To study and compare the effect of siRNA-mediated SRF or Nkx2-5 silencing on androgen-responsive genes in LNCaP cells. Human LNCaP prostate cancer cells were transfected with siRNA SmartPools targetin

NIAID Data Ecosystem20

Loss of androgen signaling in mesenchymal sonic hedgehog responsive cells diminishes prostate development, growth, and regeneration

性腺发育机制

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Prostate embryonic development, pubertal and adult growth, maintenance, and regeneration are regulated through androgen signaling-mediated mesenchymal-epithelial interactions. Specifically, the essent

NIAID Data Ecosystem60

Epigenomic and transcriptomic profiles a of prostate cancer cell line with and without androgen stimulation

前列腺癌表观基因组学

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We performed H3K27ac ChIP-seq, ATAC-seq, and RNA-seq in LNCaP with and without androgen stimulation Overall design: H3K27ac ChIP-seq, ATAC-seq, and RNA-seq in LNCaP with and without androgen stimulati

NIAID Data Ecosystem30

androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng. Mus musculus

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