Predictors of events.

Comparisons of the middle three quintiles with the top quintile (“high”) and lowest quintile (“low”) for possible predictors of events. Mean survival times to events given in days, with p values (in brackets) for the difference in risk compared with the middle 60% of the population. Significant (pN,N-dimethylglycine. AMI: acute MI. HF: hospital admission for heart failure. Betaine excretions expressed as mmol betaine/mole creatinine. Plasma betaine and DMG concentrations are gender corrected; male values cited (female values 17% lower for betaine, 10% lower for DMG).