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Pyrrolysyl-tRNA synthetase from Canditatus Methanomethylophilus alvus (MmaPylRS)

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非标准氨基酸插入

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https://www.rcsb.org/structure/6EZD 数据链接链接失效反馈

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Pyrrolysyl-tRNA synthetase from Canditatus Methanomethylophilus alvus (MmaPylRS)

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创建时间：

2024-01-17

噬菌体进化

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Genome sequencing of T7 bacteriophage to understand evolutionary dynamics on different host genetic codes

NIAID Data Ecosystem90

Development of Amber Suppressing Helper Phage

噬菌体展示

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To develop an amber suppressing helper phage for improving the efficiency of genetic code expansion in phage display.

NIAID Data Ecosystem70

Details of the orthogonal pairs used for the in vivo incorporation of Tyr analogs into hSOD1(W33TAG).

非天然氨基酸

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The pairs consist of E. coli TyrRS, or a mutant descendant, and E. coli amber suppressor tRNACUA. The aaRSs are expressed under the strong, constitutive ADH1 promoter (refer to Figure S1 for plasmid m

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Progress toward the evolution of an organism with an expanded genetic code

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非天然氨基酸

Several significant steps have been completed toward a general method for the site-specific incorporation of unnatural amino acids into proteins in vivo. An “orthogonal” suppressor tRNA was derived fr

PubMed Central1999-04-27 更新80

Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with TeocLys

蛋白质晶体结构解析

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Crystal structure of Methanosarcina mazei PylRS(Y306A/Y384F) complexed with TeocLys Descriptor: (2S)-2-azanyl-6-(trimethylsilylmethoxycarbonylamino)hexanoic acid, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM

Protein Data Bank Japan2023-11-22 更新40

Pyrrolysyl-tRNA synthetase from Canditatus Methanomethylophilus alvus (MmaPylRS)

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