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Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-kB-mediated production of CXCL1

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE160592
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资源简介:
This study sought to determine the role of Apolipoprotein E (ApoE) in mediating immune suppresion in pancreatic cancer. Our data show ApoE regulates T cell infiltration through NF-kB mediated Cxcl1 production. This dataset includes 7940b tumor cells derived from the KrasLSL-G12D/+; Trp53LSL-R172H/+; Pdx1-Cre (KPC) mouse model of pancreatic cancer treated with either vehicle or 0.3ug/mL of murine recombinant ApoE (rApoE). Vehicle (n=3) and rApoE (n=3).
创建时间:
2021-06-04
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