Synthesis and characterization of maleimide-based dual GSK3b-CK1d inhibitors (DK and FFS series)

The maleimide-based compounds described herein are potential MTDLs (Multi-Target-Directed Ligands) designed by merging the pharmacophores of single target molecules active against the two targets of interest, namely GSK3-beta and CK1-delta. Most of these compounds show activity towards the two targets with a slight preference to GSK3-beta, while some suffer from unfavourable physicochemical properties.This dataset contains:- The free induction decay (fid) of 1H and 13C NMR spectra registered on a Bruker spectrometer working at 600 MHz and at 150 MHz of the new compounds, along with PDF images of the integrated corresponding spectra for each compound. The analysis of the spectra was performed using MNova 14.2.- PDF documents with the general synthetic procedures used to obtain the target molecules- A PDF document containing the structures of the new compounds- PDF documents of the LCMS spectra of the described compounds