Bronchial epithelial microRNA expression profiling in type 2-low and type 2-high asthma

Bronchial epithelial brushings were obtained by bronchoscopy from 8 steroid-naïve asthmatics including type 2-low (n=4) and type 2-high asthma (n=4), and 4 healthy controls. The type 2-low and –high asthma was defined by the epithelial expression of a three-gene signature for type 2 status (POSTN, SERPINB2, and CLCA1). The differentially expressed miRNAs were identified between: 1) asthmatics versus healthy controls; 2) type 2-high asthma versus type 2-low asthma.