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Expression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation

ChEBI2013-06-18 更新2026-07-21 收录

肿瘤发生机制

黏液样脂肪肉瘤

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-48030 数据链接链接失效反馈

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资源简介：

Expression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation

应用场景：

创建时间：

2013-06-18

基因表达分析

肿瘤发生机制

We compared lung mRNA expression profiles between RAG1-/- control and RAG1-/- Sgo1-/+ chromosome instability model mice. RAG1-/-Sgo1-/+ mice developed significantly more spontaneous lung tumors. Char

NIAID Data Ecosystem80

Wnt-Induced Stabilization of KDM4C Is Required for Wnt/beta-Catenin Target Gene Expression and Tumorigenesis

Wnt信号通路表观遗传

肿瘤发生机制

Wnt/beta-catenin signaling is essential for stem cell regulation and cancer formation by activation of target genes transcription. For transcriptional activation, the histone around promoters needs to

NIAID Data Ecosystem40

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

肿瘤发生机制

FGF信号通路

Hepatocyte growth factor/scatter factor (HGF/SF) is a mesenchymally derived, multifunctional paracrine regulator possessing mitogenic, motogenic, and morphogenetic activities in cultured epithelial ce

PubMed Central1997-01-21 更新40

Identification of a novel TINCR-EGFR signaling pathway loop which initiates receptor tyrosine kinases cascade and confers tumorigenesis in human cancer

癌症信号通路

肿瘤发生机制

RNA sequencing was performed to investigate the potential crosstalk between TINCR and microRNAs. Overall design: microRNA profiles of T47D with TINCR knockdown and scramble were generated by deep sequ

NIAID Data Ecosystem50

Expression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation

黏液样脂肪肉瘤

肿瘤发生机制

Although different sarcomas have been modeled in mice upon expression of fusion oncogenes in MSCs, sarcomagenesis has not been successfully modeled in human MSCs (hMSCs). We report that FUS-CHOP, a ha

NIAID Data Ecosystem40

Expression of FUS-CHOP fusion protein in immortalized/transformed human Mesenchymal Stem Cells drives mixoid liposarcoma formation

资源简介：

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