Mouse Embryo Sox1 cre-dependent knockout of EED

Floxed EED homozygote mice are knocked-out by Sox1-driven Cre to remove H3K27me3 during neurogenesis Control mice are compared to EED-cKO mice in bulk RNAseq, in dissected forebrain and spinal cord采用Sox1驱动的Cre重组酶对Floxed EED纯合子小鼠进行基因敲除，以在神经发生过程中去除组蛋白H3赖氨酸27三甲基化（H3K27me3）；针对解剖分离的前脑与脊髓组织开展批量RNA测序（bulk RNAseq），并将野生型对照小鼠与EED条件性敲除（EED-cKO）小鼠的测序结果进行对比分析。