Catalytic Asymmetric Synthesis of Stable Oxetenes via Lewis Acid-Promoted [2 + 2] Cycloaddition
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https://figshare.com/articles/dataset/Catalytic_Asymmetric_Synthesis_of_Stable_Oxetenes_via_Lewis_Acid_Promoted_2_2_Cycloaddition/2569588
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资源简介：
A highly enantioselective and atom-economical [2 + 2] cycloaddition of various alkynes with trifluoropyruvate using a dicationic (S)-BINAP–Pd catalyst has been established. This is the first enantioselective synthesis of stable oxetene derivatives, whose structure has been clarified by X-ray analysis. This catalytic process offers a practical synthetic method for oxetene derivatives (catalyst loading: up to 0.1 mol %), which can serve as novel chiral building blocks for pharmaceuticals and agrochemicals and can also be transformed into a variety of enantiomerically enriched CF3-substituted compounds with high stereoselectivity.
创建时间：
2016-02-22
