CDK10 suppresses nucleic acid sensors-mediated antitumor immunity [scRNA-Seq]

Cdk10 knockout significantly reduced CT26 tumor growth in immunocompetent BALB/c WT mice. To investigate how Cdk10 influences the tumor immune microenvironment in vivo, we performed single-cell RNA sequencing (scRNA-seq) on WT and Cdk10 KO CT26 tumors derived from immunocompetent BALB/c mice. Overall design: We subcutaneously inoculated sgControl and sgCdk10 CT26 cells into immunocompetent BALB/c WT mice,and single-cell sequencing was performed