Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione

Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione Descriptor: 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F. Deposit date: 2013-02-28 Release date: 2013-08-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. J.Med.Chem., 56, 2013

通过构象调控提升FK506结合蛋白51（FK506-Binding Protein 51，FKBP51）配体的结合效率：FKBP51与化合物1-[(9S,13R,13aR)-1,3-二甲氧基-8-氧代-5,8,9,10,11,12,13,13a-八氢-6H-9,13-亚氨基氮杂环辛[2,1-a]异喹啉-14-基]-2-(3,4,5-三甲氧基苯基)乙二酮的复合物
描述物：1-[(9S,13R,13aR)-1,3-二甲氧基-8-氧代-5,8,9,10,11,12,13,13a-八氢-6H-9,13-亚氨基氮杂环辛[2,1-a]异喹啉-14-基]-2-(3,4,5-三甲氧基苯基)乙二酮、二甲基亚砜、甘油……
作者：王, Y、基尔施纳, A、法比安, A、戈帕拉克里希南, R、克雷斯, C、胡格兰, B、科赫, U、科扎尼, C、布拉彻, A、豪施, F
提交日期：2013-02-28
发布日期：2013-08-28
最后修改日期：2024-02-28
实验方法：X射线衍射（1.05 Å）
引用文献：《通过构象调控提升FK506结合蛋白51配体的结合效率》，《药物化学杂志》，56卷，2013年