Crystal structure of human KRAS G12C covalently bound to AM-8719

Crystal structure of human KRAS G12C covalently bound to AM-8719 Descriptor: 1-(4-{(2R,3R)-1-[6-{4-[2-(3-methoxyoxetan-3-yl)-4-methylpyridin-3-yl]piperidin-1-yl}-2-(trifluoromethyl)pyrimidin-4-yl]-2-methylazetidin-3-yl}piperazin-1-yl)propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Mohr, C. Deposit date: 2026-04-10 Release date: 2026-08-12 Last modified: 2026-08-26 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor. J.Med.Chem., 69, 2026