Global Identification and Characterization of tRNA-Derived RNA Fragment Landscapes across Human Cancers

Transfer RNA-derived RNA fragments (tRFs), a novel class of small non-coding RNAs, are abundant in many organisms, yet their role in cancer remains largely unexplored. Here, we report a functional genomic landscape of tRFs in 8,118 specimens across 15 cancer types from The Cancer Genome Atlas. To benefit the research community, we developed a web-based data portal, OncotRFdb (http://bioinformatics.zju.edu.cn/OncotRFdb/). Our study also provides a valuable tRF resource for identifying diagnostic and prognostic biomarkers, developing cancer therapy and studying cancer pathogenesis.